Applikon bioreactor user manual

Coleparmer has one of the best websites ive ever used for purchasing items from a company. User manual biosep adi1015 september 2001 7 0 1x10 72x107 3x10 0 20. The color touch screen interface guides the user through the intuitive operation. Stainless steel bioreactors the applikon stainless steel bioreactor range is divided into a microbial range and a cell culture range of volumes. Applikon can guide a customer through the whole upstream process, from initial screening up to fullscale production. With simple changes in configuration the biobundle system can be modified for different applications in a costeffective way. The cell culture process requirements for biotechnology drugs have become increasingly challenging, with a drive for process intensification. Bioxpert lite data acquisition program user manual, applikon biotechnology. Open frame construction gives easy access for maintenance and operation.

Before addition of bacteria, the ph and oxygen sensors must be calibrated, the impeller speed set and the temperature set. Cost of setting up a bioreactor is challenge faced while constructing one. How to set the pid parameter values for dissolved oxygen control. The system is straightforward to operate and provides. Bioxpert lite data acquisition program user manual, applikon biotechnology, software version 1. Bioprocess controllers thermo fisher scientific us. Sartorius supports every customer with a fully scalable and interchangeable range of singleuse or glass and stainless steel bioreactor solutions. I do not have a lot of experience on pid tuning for dissolved oxygen control by. Easy operation through touch screen interface and through web browsers.

Offering new functionality, a high level of flexibility and improved performance the generation 2 system is ideally suited for applications including. Repligen develops and manufactures products for the biopharmaceutical industry under an iso 9001 quality management system. Measure the temperature of the ph buffer standards using a thermometer. Applikon bioreactor the unique micromatrix offers total control over 24 independent bioreactors in a simple microtiter plate footprint. Smallvolume bioreactors minimize costs and use less of valuable bench space. The icellis bioreactor system is an automated, singleuse, fixedbed bioreactor that provides excellent cell growth conditions for adherent cells. Find great service and an excellent selection of fermentation products at coleparmer.

The bioreactor can be run with or without the iris software. Single use bioreactors are said to heavily cut down costs of setting up a bioreactor. Glass autoclavable bioreactors and fermentors are available in 1 2 3 5 7 15 and 20 liter total volume. Applikon biotechnology is a world leader in developing and supplying advanced bioreactor systems for the production of vaccines, antibodies, tissues, biopharmaceuticals, nutraceuticals and biosimilars in the pharmaceutical industry, as well as enzymes, food, feed, biofuel, biochemicals and bioplastics for industrial biotechnology. Benchtop bioreactor with all parts labeled and connected. Applikon ezcontrol bioreactor controller operation before the bioreactor is autoclaved, the ph acidity sensor needs to be calibrated with ph 4. In the laboratory bioreactor and fermentor range applikon is worldwide market. Autoclavable bioreactor 2 7 liter user manual appiikorf dependable instruments v3ubce0061. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers. Braun fermentor the biostat c is a compact, laboratory scale fermenter with insitu sterilizable 10 litres culture vessel. How to set the pid parameter values for dissolved oxygen. Applikon minibio lab reactor bundles from coleparmer.

Common challenges of bioreactors biotechnologyforums. The stirred tank reactor str is the most widely used bioreactor type. The o2 electrolyte used in the do probe is a strong alkaline ph solution. The bioreactor is filled with media, and a small sample of media is retained for later use as a spectroscopic blank. Applikon bioreactor fermentor system system includes. Applikon adi 1010 bio controller applikon adi 1025 bio console. O 2 meter for minifor laboratory fermenterbioreactor operation manual pdf. However to capture data, it is best to use the software.

Used applikon adi 1025 fermenter for sale dotmed listing. Pharma bioreactors gea engineering for a better world. The my control offers advanced and userfriendly control on a very limited bench space. In figure 2, the data output for a bioreactor run is presented. Utilizing the strong synergies in bioreactor technology and polymer manufacturing, eppendorf has emerged as a global player and valuable resource to its customers in the bioprocess marketplace. The thermo scientific hyperforma g3lite controller is an open architecture control system that can be integrated with any singleuse bioreactor such as the thermo scientific hyperforma singleuse bioreactor s. Each of the 24 bioreactors on a plate offer independent controls like its larger stirredtank relatives. This results in low initial investment and low running costs. Applikon benchtop bioreactor manufacturer instrumentation manuals 4. Applikon fermentationbioreactor porous sparger tip for 10. The intuitive color touch screen interface guides the user through the various operations. Until now, the costs of mass production bioreactors meant for large scale production of those like bio fuels, are not at all as low as to extract all the positives of a bioreactor. The sodium bicarbonate solution is very basiccaustic. The applikon 2 7 liter autoclavable bioreactors offer several advantages.

The applikon autoclavable bioreactor systems basically consist of the following parts. Metrohm applikon is pleased to present a robust solution anpan10 for the online monitoring of boric acid in cooling waters of pressurized water reactors pwrs. The front of the bioreactor has an onoff switch that powers up the unit. This figure shows the stirred tank reactor at the beginning of a run. Instruction manual zenith bioreactor model bioferm0103 page 11 zenith engineers no. Biobundle, complete cultivation systems applikon biotechnology. Bench scale and pilot plant steaminplace bioreactor systems. Mini4gas automatic gas mix software user guide pdf, 8 kb siam industrial fermentation software user guide pdf, 2, mb lambda redox potential orp measurement for minifor laboratory bioreactor operation manual pdf, 603 kb lambda lumo light intensity controller for minifor fermentor and bioreactor operation manual pdf, 761 kb. Applikon lucullus, process information management system.

The system consists of a control tower that leverages intelligent transmitters. Hardware manual ezcontrol for autoclavable bioreactor systems 1 20 l general september 2008 1 1 general 1. Glass autoclavable bioreactors applikon biotechnology. The microbial sterilizableinplace bioreactor systems come in a total volume of 15 l, 20 l, 30 l, 40 l, 70 l and 140 l.

It enables to avoid delicate and time consuming manual operations. Compared to standard stirred tank bioreactor using microcarriers, the icellis technology leads to a dramatic simplification of cell culture process. Stainless steel bioreactors applikon biotechnology. Available with very short delivery times, our bioreactors ensure longterm sterility during medium or nutrient change, aseptic sampling, aeration, venting or transfer, highly accurate temperature control, and stirrers that are adapted to provide efficient mixing while keeping shear stress to a minimum. Includes 6l glass vessel, computer, peristaltic pump, manuals, heat mantles, tool. Montgomery county community college document number. Applikon z310110010 ezcontrol bioreactor control system. The metrohm applikon system is based on the adi 2045ti process analyzer and determines the boric acid concentration by potentiometric titration. Glass autoclavable bioreactors and fermentors are available in jacketed and single wall versions in 2, 3, 5, 7, 15 and 20 liter total volume 20 liter only in single wall version. Fedbatch, perfusion or continuous cell cultivation strategies are increasingly used to maximize productivity, leading to a growing demand for new approaches to bioreactor design, improving aeration and. Assembling guide for reuseable jacket model applikon. A biobundle is a complete bioreactor system, equipped with all necessary components. The minibio range of bioreactors is a true scaledown of the traditional laboratory bioreactor, which means you are able to achieve highthroughput bioreactor cultivation without sacrificing the quality of your experiment.

Hyperforma singleuse bioreactors is here we redesigned the all new thermo scientific hyperforma singleuse bioreactor s. Specifications autoclavable bioreactor specifications. The stirred tank reactors str are the most applied reactor types in biotechnology. Nieuwpoortweg 12 3125 ap schiedam the netherlands tel. It is equipped with oxygen and ph probes, four pumps, vessel with drive, digital measurement and control as well as connections to external systems. User manual autoclavable bioreactor 2 7 liter hardware specification october 1994 11 chapter 1 hardware specification 1. The combination of the software with the broad range of applikon bioreactor systems offer the user a unique system for validatable fast. Gea offers a range of standardised, pilotscale bioreactors for your cell culture needs. Applikon bio bench 30l jacketed stainless steel bioreactor.

User manual stirrer speed controller ad11032 for motor p100310, version 4, january 2000 safety class i apparatus this apparatus has been designed in accordance with iec10101 safety requirements for electrical equipment for measurement, control and laboratory use, and has been supplied in a safe condition. The array of automated multiparallel mini bioreactors and classic benchtop bioreactors supports fast and reliable development and characterization of your processes throughout all phases. Frequently the term fermenter is used in the literature to mean bioreactor. When you are running your bioreactors controlled by our adi 1010 or adi 1030 bio controllers, the incontrol can be used to increase the capabilities of your bioreactor system with a minimal investment and no downtime for your process. The incontrol offers highlevel control on a small footprint. This sop provides the basic steps required to cultivate a cell culture using the applikon ezcontrol and a 3liter glass autoclavable bioreactor. Cell culture process simplification, from vial to product. Applikon air outlet pipe bioreactor 315 hearstmarch 23rd, 2018. Insitu sterilizable glass fermenterbioreactorvertical.